Combine water and yeast in the bowl of a stand mixer, and allow to sit until yeast blooms, about 5 minutes. With the mixer's paddle attachment, stir in the milk, 5 tablespoons melted butter, sugar, egg and salt, mixing on low speed until well combined. Gradually add in the flour, 1/2 cup at a time, mixing on low speed to incorporate after each addition and adding enough flour to yield a dough that is moist but not sticky. Outfit the mixer with the dough hook, and knead with the machine on medium speed for 5-7 minutes, or until dough is smooth and elastic. Place the dough is an oiled bowl, and allow to rise until doubled in bulk, about 1 hour.

Place cranberries in a microwave-safe bowl and cover with water. Microwave on high until water boils, about 1 minute. Drain water and allow cranberries to cool.

In a small bowl, mix together the 1/4 cup granulated sugar, cinnamon and orange zest. Set mixture aside.

Gently punch down the dough, and turn onto a floured surface. With a rolling pin, roll the dough into a 8x18-inch rectangle. Brush the surface of the dough with the 1 tablespoon melted butter and sprinkle with the cinnamon-sugar-zest mixture, reserving 2 teaspoons of the mixture for sprinkling onto the top of the loaf before baking. Spread the cranberries evenly over the surface. Starting at one of the 8-inch ends, roll the dough tightly in a jelly roll fashion, pinching the ends and seams closed. Place seam side down in a greased 9x5-inch loaf pan, and allow to rise until doubled in bulk, about 1 hour.

Preheat oven to 375. In a small bowl, whisk together the 1 egg and pinch of salt. Brush the mixture evenly over the surface of the bread and sprinkle with the reserved cinnamon-sugar-zest mixture. Bake for approximately 40 minutes, until bread is browned and the top sounds hollow when tapped. Turn the loaf onto a wire rack and allow to cool for 10-15 minutes.

While bread cools, prepare the glaze. In a medium bowl, combine the powdered sugar, milk and vanilla, whisking well until smooth and adding more sugar or milk as needed to achieve the desired consistency. Drizzle glaze over warm loaf.